8.4 – The intestinal stem cell niche: key to regeneration and immunity – Sevens Nutrition

The intestine completely renews itself every 3 to 5 days. This rapid regeneration rate is possible thanks to intestinal stem cells , located at the base of the crypts of the small and large intestine. They are responsible for replacing millions of epithelial cells daily, maintaining the integrity of the intestinal barrier, and ensuring efficient nutrient absorption.

Over time, the environment where these cells reside—known as the intestinal niche —is affected by chronic inflammation, oxidative stress, dysbiosis, and immune decline , compromising their ability to renew themselves. The result: increased intestinal permeability, a higher risk of infections, dysbiosis, food sensitivities, and inflammatory diseases.

What depletes intestinal stem cells?

Persistent infections or prolonged use of antibiotics.
Pro-inflammatory diets (ultra-processed foods, excess sugar and trans fats).
Exposure to environmental toxins.
Dysbiosis: loss of beneficial bacteria.
Deficiency of micronutrients essential for epithelial regeneration.

When this niche fails, not only digestion deteriorates , but also immunity, nutrient absorption, mood, and even metabolism.

Sevens products to support intestinal regeneration and the stem cell niche

Organic Turmeric Sevens

It has a local anti-inflammatory effect on the intestine, supports beneficial microbiota, and modulates the intestinal immune system. It promotes epithelial integrity and regeneration.

Biotin Sevens

It contributes to the maintenance of mucous membranes and promotes the regeneration of the intestinal epithelium , especially in cases of increased permeability or chronic dysbiosis.

Sevens Multivitamins

It provides zinc, vitamins A, B9 and B12, essential for the renewal of enterocytes , the regulation of the intestinal immune system and local energy production.

Magnesium Sevens

It helps maintain the acid-base balance of the intestine, regulates intestinal motility, and supports enzymes involved in metabolism and cell differentiation of the epithelium.

Detox Sevens

It promotes liver function and the elimination of toxins that could damage the intestinal mucosa or interfere with the microenvironment of intestinal stem cells.

Omega 3 Sevens (fish oil)

It reduces intestinal inflammation, improves the immune response of the mucous membranes , and promotes the repair of damaged intestinal tissue.

Key habits to preserve the intestinal niche:

Eat prebiotic and fiber-rich foods (vegetables, fruits, seeds).
Reduce consumption of alcohol, ultra-processed foods, and sugar.
Sleep well and manage stress, which directly impacts the intestinal barrier.
Perform short fasts or digestive breaks to facilitate epithelial regeneration.

Conclusion

Gut health is inseparable from longevity and regeneration. Intestinal stem cells support one of the body's most vital systems. Protecting their environment with a strategy like Sevens'—focused on anti-inflammation, detoxification, cellular nutrition, and microbiota—can strengthen immunity, restore nutrient absorption, and rejuvenate from the core of the body outward.