8.3 – Stem cells and brain aging: plasticity, memory and neurogenesis – Sevens Nutrition

For a long time, it was thought that the adult brain could not regenerate. Today, we know that in regions such as the hippocampus and subventricular zone, there are neural stem cells capable of generating new neurons, glia, and synaptic connections. These stem cells are essential for brain plasticity, memory, learning, and injury repair.

With aging, these stem cells decrease in number and activity . Their environment (neurogenic niche) becomes more inflamed, less oxygenated, and exhibits dysfunctional metabolic signals. The result: decreased neurogenesis, increased susceptibility to cognitive decline, and a reduced mental capacity to adapt to stress or change.

Factors affecting brain stem cell function

Chronic neuroinflammation (activation of proinflammatory microglia).
Excess free radicals and mitochondrial dysfunction.
Disruption of circadian rhythms and lack of restorative sleep.
Low production of neurotrophic factors (such as BDNF).
Lack of essential nutrients for neurogenesis.

The decline of these cells directly affects the brain's ability to renew itself, remain agile, and adapt throughout life.

Sevens support to stimulate brain regeneration

Curcumin C3 Reduce Sevens

It activates pathways such as BDNF and NRF2, reduces neuroinflammation, stimulates neuronal autophagy, and protects the brain stem cell niche. It has the ability to cross the blood-brain barrier.

Omega 3 Sevens (fish oil)

DHA is essential for neuronal membranes. It enhances synaptogenesis, protects against oxidative stress, and stimulates neurogenesis in the hippocampus.

Sevens Multivitamins

It provides B6, B12, folate and vitamin C, essential for brain methylation, neurotransmitter synthesis and the maintenance of neuronal plasticity.

Melatonin Sevens

It promotes deep sleep and regulates the brain's nocturnal cleansing (glymphatic system). It also activates longevity genes such as SIRT1 and supports the differentiation of new neurons.

Astaxanthin Sevens

It protects brain tissue from lipid oxidation, preserves the integrity of neurons and mitochondria, and improves mental acuity and cognitive endurance.

Creatine Sevens

Optimizes brain energy, improves mood, motivation, and working memory. Helps boost the activity of neural networks undergoing renewal.

Complementary habits:

Regular physical exercise (especially moderate aerobic).
Deep and consistent sleep.
Cognitive training or continuous learning.
Diet rich in polyphenols, omega 3 and neuroprotective micronutrients.

Conclusion

Neurogenesis doesn't stop with age, but it does weaken if we don't nourish it. By caring for our brain stem cells with an approach like the one Sevens proposes—focused on functional nutrition, specialized antioxidants, and mitochondrial support—we can protect memory, maintain mental agility, and delay cognitive aging from within .