9.3 – Altered hormonal communication: resistance to insulin, leptin an – Sevens Nutrition

Hormones are the "chemical messengers" that allow distant organs to communicate with each other. They act on specific receptors in cells and tell them when to grow, rest, burn fat, absorb glucose, regenerate, or defend themselves. But over time—and due to stress, inflammation, or bad habits—many cells stop responding appropriately to these signals . This is called hormonal resistance .

The most common forms are:

Insulin resistance : glucose does not enter cells well and accumulates in the blood.
Leptin resistance : the brain does not perceive that there are sufficient energy reserves and appetite is deregulated.
Cortisol resistance : the stress axis is altered and the state of alarm becomes chronic.

These hormonal disruptions cause internal chaos that affects energy, metabolism, regeneration and body composition .

What causes hormonal resistance with age?

Chronic systemic inflammation.
Accumulation of visceral fat and high glucose.
Continuous exposure to stress and disruption of the circadian rhythm.
Deficiencies of micronutrients essential for hormonal signaling.
Physical inactivity and alterations in the intestinal microbiota.

All of this prevents cells from correctly listening to the orders that hormones try to transmit, impairing the body's functional communication.

Sevens products that help restore hormonal sensitivity and improve cell signaling

Magnesium Sevens

An essential cofactor for insulin and cortisol receptors. It improves insulin sensitivity, modulates the stress response , and supports blood sugar regulation.

Omega 3 Sevens (fish oil)

It reduces the inflammation that generates hormonal resistance. It improves leptin and insulin signaling, promotes metabolic flexibility, and reduces glucotoxicity.

D3 + K2 Sevens

Vitamin D regulates insulin receptor gene expression and strengthens immune-endocrine communication. K2 contributes to cardiovascular health, especially in contexts of metabolic dysfunction.

Curcumin C3 Reduce Sevens

It modulates hormonal and inflammatory pathways, especially in adipose and liver tissue. It helps restore sensitivity to signals such as leptin and insulin.

Sevens Multivitamins

It provides chromium, zinc, B vitamins and antioxidants necessary for the synthesis and activation of hormone receptors , as well as for effective intracellular signaling.

Melatonin Sevens

It regulates the circadian rhythm and the HPA (hypothalamus-pituitary-adrenal) axis, promoting a healthy cortisol balance and deep regenerative rest.

Recommendations to restore hormonal communication

Prioritize strength training and moderate aerobic exercise.
Get a good night's sleep and avoid screens before bed.
Maintain adequate protein and fiber intake.
Reduce sugar, refined flours, and heavy nighttime meals.
Incorporate fasting windows (12–14h) to regain insulin sensitivity.

Conclusion

Hormonal resistance is a disconnect: hormones keep talking, but cells stop listening. Restoring that conversation is key to recovering metabolism, energy, regeneration, and longevity. With Sevens' holistic approach—focused on key nutrients, circadian synchronization, stress management, and anti-inflammation—it's possible to restore hormonal balance from within , and with it, regain the adaptability that defines youthful biology.