The brain is one of the organs most sensitive to imbalances in proteostasis , that is, malfunctions in the system that regulates protein production, folding, repair, and degradation. Since neurons are highly specialized cells with limited capacity for self-renewal, the accumulation of misfolded or damaged proteins can have devastating consequences for cognitive and neurological function.

Numerous studies have established a direct connection between the loss of proteostasis and the development of neurodegenerative diseases such as Alzheimer's , Parkinson's , amyotrophic lateral sclerosis (ALS) , and frontotemporal dementia . These pathologies share a common pattern: the formation of toxic protein aggregates in nervous tissue.

Protein aggregates in the brain: the result of altered proteostasis

Throughout life, neurons synthesize millions of proteins. Under normal conditions, misfolded proteins are corrected by chaperones or degraded by the proteasome and autophagy. However, with age:

• Decreases the production of molecular chaperones .

• The proteasome becomes less efficient.

• The autophagic capacity of cells is reduced.

This deterioration leads to the accumulation of aberrant proteins, such as:

• Beta-amyloid in Alzheimer's, which forms toxic extracellular plaques.

• Hyperphosphorylated tau protein , which interferes with the internal structure of the neuron.

• Alpha-synuclein in Parkinson's, which forms Lewy bodies and disrupts synapses.

These proteins not only lose their function, but also alter neuronal signaling, causing inflammation, oxidative damage, and ultimately cell death.

The vicious circle between proteostasis and neuroinflammation

The accumulation of misfolded proteins not only directly affects neurons but also activates glial cells (such as astrocytes and microglia), generating a sustained inflammatory response. This chronic neuroinflammation , in turn, further impairs cells' ability to handle defective proteins, leading to a cycle of progressive deterioration.

Strategies to protect brain proteostasis through nutrition and supplementation

Various nutritional compounds have demonstrated positive effects in improving protein health and preventing toxic aggregates in the nervous system:

• Curcumin , the active ingredient in Curcuma Sevens , crosses the blood-brain barrier and has demonstrated neuroprotective, anti-inflammatory, and autophagy-enhancing effects. It may contribute to the removal of amyloid plaques and the control of oxidative stress in the brain.

• Omega-3 Sevens , high in DHA, is essential for the structure of neuronal membranes, improves synaptic plasticity, and positively modulates brain inflammation. Studies have linked a good EPA/DHA ratio with a lower risk of cognitive decline.

• Magnesium Sevens , a mineral essential for nervous system function, acts as a modulator of neuronal excitability and is a cofactor in neurotransmitter synthesis. Magnesium deficiency is associated with cognitive decline and increased vulnerability to neuronal stress.

• Sevens Multivitamins provides B vitamins (B6, B12 and folic acid) necessary for the synthesis of neurotransmitters, DNA methylation and the reduction of homocysteine, a marker related to cognitive decline and neurodegeneration.

Complementary habits that boost brain health and proteostasis

• Regular physical exercise, which stimulates neurogenesis and activates neuronal autophagy.

• Quality sleep is essential for the nighttime elimination of accumulated proteins (via the glymphatic system).

• Cognitive and social stimulation, which strengthens neuronal connections and synaptic plasticity.

• Intermittent fasting or mild calorie restriction strategies, which activate cellular cleansing mechanisms.

Conclusion

The brain ages, in part, because it loses the ability to efficiently manage its proteins. The loss of proteostasis in the nervous system is one of the root causes of cognitive decline and neurodegenerative diseases. However, through evidence-based nutritional interventions and the support of strategic supplements like those offered by Sevens, it is possible to support brain health, slow neurological aging, and preserve cognitive function over time.