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5. Nutrient Detection Failure:

Nutrient sensing and response is crucial for metabolic homeostasis. With age, this sensing system can fail, contributing to metabolic diseases and obesity. Restoring nutrient sensitivity could rebalance our metabolism and extend health into longevity.

5.1 Nutrient detection failure. Insulin insensitivity

5.2 – The role of insulin and its deterioration with age: how does it affect aging?

5.3 – Sirtuins and calorie restriction: nutrient sensors with an impact on longevity

5.4 – AMPK as an energy sensor: the key to healthy metabolism in adulthood

5.5 – The role of leptin and ghrelin in nutrient perception and appetite with age

5.6 – Intestinal microbiota: its influence on the detection of nutrients and metabolic signals

5.7 – Key nutrients that modulate metabolic sensors: polyphenols, magnesium and omega-3

5.8 – The impact of excess calories on the loss of nutrient sensitivity

5.9 – Intermittent fasting strategies to restore metabolic sensitivity

5.10 – Comprehensive Sevens strategy to improve nutrient detection and response