Group 5 of this series is dedicated to one of the fundamental causes of aging: nutrient sensing failure . This mechanism describes how, with age, our bodies lose precision in sensing and responding to essential nutrients. This imbalance affects hormones, cellular sensors, and metabolic pathways, contributing to the development of diseases such as obesity, type 2 diabetes, cognitive decline, and metabolic syndrome. Restoring this sensitivity can rebalance metabolism and extend functional health into longevity.

This is the first article in a 10-part series, which will address this complex process from different angles. Below is a table of contents for the topics we'll cover:

INDEX GROUP 5: Nutrient Detection Failure

1. Insulin insensitivity and its role in metabolic aging

2. How the mTOR axis responds to nutrients and ages with us

3. Sirtuins and calorie restriction: nutrient sensors with an impact on longevity

4. AMPK as an energy sensor: the key to healthy metabolism in adulthood

5. The role of leptin and ghrelin in nutrient perception and appetite with age

6. Gut microbiota: its influence on nutrient detection and metabolic signals

7. Key nutrients that modulate metabolic sensors: polyphenols, magnesium, omega-3

8. Insulin resistance in the brain and its relationship with cognitive decline

9. The role of fasting and circadian rhythms in nutrient sensitivity

10. Sevens Strategy to Restoring Nutrient Sensing in Active Longevity

As we age, our bodies progressively lose the ability to respond appropriately to certain key metabolic signals. One of the most important is insulin , the hormone that regulates the transport of glucose from the blood into cells for use as an energy source or for storage. When cells stop responding effectively to this signal, a phenomenon known as insulin resistance or insulin insensitivity occurs.

This metabolic state is one of the first signs of nutrient sensing failure , one of the fundamental causes of aging. Not only does it contribute to the development of type 2 diabetes , but it is also associated with cardiovascular disease, obesity, cognitive decline , and an overall acceleration of the aging process.

Insulin: from key hormone to neglected signal

Under normal conditions, when we eat and blood glucose levels rise, the pancreas releases insulin. This hormone binds to receptors on cell membranes, allowing glucose to enter the body for use as energy. However, factors such as excess calories, inactivity, chronic inflammation, and oxidative stress reduce the sensitivity of these receptors , forcing the body to produce more and more insulin.

Over time, this hyperinsulinemia leads to a vicious cycle of inflammation, vascular damage, mitochondrial dysfunction, and visceral fat accumulation. All of this accelerates tissue degeneration and reduces cells' ability to maintain homeostasis.

Insulin and aging: a critical connection

Numerous studies have linked insulin resistance with:

• Increased cellular oxidative stress.

• Activation of proinflammatory pathways (such as NF-kB).

• Decreased autophagy, a cellular cleanup process crucial for longevity.

• Decreased activity of AMPK, a cellular energy sensor.

• Hormonal changes that even affect brain metabolism.

Therefore, insulin insensitivity is not just a glycemic problem , but a profound manifestation of cellular dysregulation that impacts the entire organism.

Nutritional and supplemental strategies to restore insulin sensitivity

One of the best ways to maintain proper insulin signaling throughout life is through smart nutrition. Some natural compounds have been shown to improve glucose uptake or reduce underlying inflammation:

• Omega-3 fatty acids (present in Omega 3 Sevens) : help improve cell membrane fluidity, which facilitates interaction with insulin receptors. They also reduce low-grade inflammation associated with insulin resistance.

• Magnesium ( Magnesium Sevens ) : This mineral acts as a cofactor in multiple metabolic reactions related to glucose and insulin metabolism. Its deficiency is closely linked to impaired glycemic control.

• Curcumin ( BIO Sevens Turmeric ) : Compounds such as curcumin have been shown to reduce insulin resistance through the inhibition of inflammatory pathways (such as TNF-alpha and IL-6), with beneficial effects on adipose and liver tissue.

• B vitamins ( Sevens Multivitamins ) : especially B1, B6 and B12, necessary for energy metabolism and the integrity of cell receptors.

Lifestyle and hormonal regulation

Accompanying supplementation with lifestyle strategies is key:

• Regular physical exercise , especially strength training or HIIT, significantly improves insulin sensitivity.

• Quality sleep , which regulates cortisol secretion and reduces resistance.

• Intermittent fasting , a tool that can improve insulin response and reduce inflammation in healthy, older people.

• Stress management , as excess cortisol worsens the metabolic environment.