5.8 – The impact of excess calories on the loss of nutrient sensitivit – Sevens Nutrition

We live in an era of energy abundance. Every day, many people consume more calories than their bodies need, in the form of energy-dense foods that are poor in actual nutrients. This constant caloric excess not only contributes to weight gain but also impairs one of the body's most fundamental systems: its ability to detect, interpret, and respond to nutrients .

The problem isn't just what we eat, but how the sustained excess energy interferes with cellular sensors like insulin, leptin, the mTOR axis, and AMPK . This situation results in a state of metabolic resistance , where the body doesn't properly "hear" the signals it previously used to self-regulate.

How excess calories affect metabolic sensitivity

Insulin resistance : Chronically elevated levels of glucose and insulin reduce the sensitivity of cell receptors, making it difficult for glucose to enter cells and promoting excessive fat storage.
Leptin resistance : Increased body fat increases circulating leptin, but the brain stops responding, promoting overeating and perpetuating the vicious cycle.
Chronic mTOR activation : Too many nutrients permanently stimulate this pathway, preventing autophagy and cellular recycling.
AMPK inhibition : High energy status blocks the activation of this key sensor of energy balance and cellular repair.

All of this creates a metabolic environment in which cells lose their ability to interpret the real nutritional context , which accelerates aging and promotes chronic diseases such as type 2 diabetes, obesity, and metabolic syndrome.

Why does this happen with aging?

With age, metabolism slows, physical activity often decreases, and energy needs change. However, many people maintain eating patterns as if their bodies were still in their youth , leading to a silent but persistent energy overload.

Furthermore, fatty tissue tends to accumulate in metabolically active areas (such as the abdomen), where it releases pro-inflammatory cytokines that amplify insulin resistance and other metabolic imbalances.

How to reverse this state of “metabolic noise”

Reduce your consumption of empty calories : avoid added sugars, ultra-processed foods, and trans fats.
Prioritize nutrient-dense foods , rich in fiber, polyphenols, and healthy fatty acids.
Establish defined meal times : avoiding constant eating chronically activates metabolic sensors.
Implement intermittent fasting or mild calorie restriction , strategies that have been shown to restore nutrient sensitivity.

Support from Sevens to restore cellular response

Strategic use of supplements can help modulate this environment:

BIO Sevens Turmeric : Curcumin can reduce inflammation in adipose tissue and improve insulin and leptin sensitivity.
Omega 3 Sevens : Its anti-inflammatory capacity is useful for combating metabolic resistance induced by excess calories.
Magnesium Sevens : participates in the activation of AMPK and improves the efficiency of energy metabolism, being key in contexts of energy overload.

Conclusion

Excess calories aren't just a weight issue, they're a profound metabolic disturbance . Over time, this muted overeating damages the machinery that regulates how our bodies respond to nutrients, accelerating aging. Adopting a smarter diet, along with strategic supplements like those from Sevens, helps restore balance and clarity to the internal metabolic dialogue , key to functional longevity.