Within the complex network of biochemical signals that regulate how our cells perceive and respond to nutrients, sirtuins occupy a privileged place. These enzymes, especially SIRT1 , have captured the attention of aging science due to their direct relationship with calorie restriction , longevity, and the prevention of age-related diseases.
Sirtuins act as metabolic sensors : they detect the cell's energy status through NAD⁺ levels (a coenzyme that declines with age) and regulate key processes such as DNA repair, mitochondrial function, inflammation, and apoptosis . They are, in essence, guardians of cellular stability when nutrients are scarce.
Sirtuins and longevity: the scientific connection
In animal models, activation of sirtuins by caloric restriction or fasting has been shown to:
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Extending life expectancy.
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Improved cognitive function.
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Reduction of systemic inflammatory markers.
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Preservation of muscle mass and insulin sensitivity.
This effect depends not only on eating less, but also on activating a series of cellular responses that optimize energy use and strengthen repair systems. This is why sirtuins are considered key therapeutic targets in biogerontology .
How to activate sirtuins without starving?
Although calorie restriction is one of the most direct ways to activate sirtuins, there are other complementary pathways:
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Moderate and sustained physical exercise .
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Intermittent fasting , which simulates the metabolic effects of scarcity without causing deficiencies.
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Nutrients and bioactive compounds that promote NAD⁺ production or directly activate sirtuins.
Natural compounds that promote the action of sirtuins
Some ingredients have been widely studied for their ability to activate these enzymes:
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Polyphenols , such as resveratrol and curcumin , which act as indirect activators of sirtuins.
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Magnesium , which contributes to mitochondrial energy metabolism, where many sirtuins perform their function.
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Omega-3 , for its anti-inflammatory capacity, which allows a more favorable cellular environment for repair and longevity.
In this context, Sevens products such as:
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BIO Sevens Turmeric (rich in curcumin),
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Omega 3 Algae Sevens (EPA and DHA),
They can play a synergistic role in supporting these mechanisms. They don't act as drugs, but they create the right metabolic environment for cellular pathways related to longevity to function more efficiently.
Conclusion
Sirtuins are one of the most fascinating bridges between nutrient sensing and healthy aging. Activating them naturally through diet, fasting, and certain nutrients is not only possible, but desirable. With a comprehensive approach like the one promoted by Sevens, we can intervene in these processes through prevention and daily care, building a path to greater vitality and long-term cellular balance.