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8.8 – Physical exercise and stimulation of endogenous stem cells

8.8 – Ejercicio físico y estimulación de células madre endógenas

Physical exercise is, without a doubt, one of the most effective strategies for stimulating the body's regenerative activity . Beyond its cardiovascular and metabolic benefits, movement directly and indirectly activates multiple types of endogenous stem cells in tissues such as muscle, brain, gut, bone, and skin.

When we train, especially through strength training or moderate aerobic exercise, molecular signals (such as myokines, BDNF, IGF-1, and anabolic hormones) are released that activate stem cell proliferation and differentiation, promoting tissue regeneration and rejuvenating the cellular microenvironment.


How does exercise stimulate regeneration?

  • Increases blood flow and oxygenation of cellular niches.

  • Reduces chronic inflammation (inflammaging) and improves insulin sensitivity.

  • It stimulates anabolic pathways (such as AMPK and mTOR) that activate cell proliferation.

  • Improves mitochondrial biogenesis and resilience to oxidative stress.

  • It activates neurogenesis (formation of new neurons) and myogenesis (new muscle fibers).

Even in advanced age, exercise can reactivate dormant stem cells , especially in skeletal muscle, the brain, and the gut.


Sevens products that enhance the effects of exercise on stem cells

Creatine Sevens

It promotes muscle regeneration, improves strength, and stimulates the activation of muscle satellite cells , which are essential for preventing sarcopenia. It also enhances neuroplasticity.

Magnesium Sevens

It regulates muscle contraction, energy production, and post-workout repair. It optimizes mitochondrial enzyme activation necessary for cell proliferation.

Sevens Multivitamins

It provides key nutrients (B12, C, D, zinc, iron) for protein synthesis, immune response and the production of trophic factors that activate stem cells after exercise.

Astaxanthin Sevens

Reduces exercise-induced oxidative damage, improves recovery, and protects the mitochondria of activated stem cells. Powerful systemic antioxidant support.

Omega 3 Sevens (fish oil)

It modulates inflammation induced by physical exertion, improves the anabolic sensitivity of muscle tissue and facilitates post-exercise regeneration.

D3 + K2 Sevens

Vitamin D regulates the expression of genes related to cell regeneration, bone health, and immune system balance. K2 promotes healthy vascularization.


Practical recommendations

  • Combine aerobic exercises (walking, swimming, cycling) with strength exercises (weights, calisthenics).

  • Respect recovery times to promote cell proliferation.

  • Exercise outdoors to synchronize circadian rhythms and stimulate natural vitamin D production.

  • Hydrate well and take care of your post-exercise diet: it's the key time for regeneration.


Conclusion

To move is to regenerate. Exercise is a tool capable of reactivating the body's innate ability to repair and renew itself by stimulating stem cells in multiple tissues. Combined with a supplemental strategy like Sevens, focused on cellular recovery, redox balance, and mitochondrial support, exercise becomes a first-line therapeutic intervention for functional longevity.