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7.6 – Senescence in the nervous system: cognitive fatigue and neuronal deterioration

7.6 – Senescencia en el sistema nervioso: fatiga cognitiva y deterioro neuronal

As we age, not only does our physical energy decrease, but we can also experience memory loss, difficulty concentrating, and mental fatigue . These changes are closely linked to the accumulation of senescent cells in the nervous system , a phenomenon that contributes to cognitive decline and neurodegenerative diseases such as Alzheimer's and Parkinson's.

Although neurons have a limited capacity to divide, other brain cells, such as astrocytes, microglia, and progenitor cells , do enter senescence. These aging cells stop performing support and cleanup functions and begin releasing SASPs, impairing neuroplasticity, promoting chronic inflammation, and disrupting communication between neurons.


Consequences of brain senescence

  • Increased production of inflammatory cytokines (IL-6, TNF-α) in brain tissue.

  • Increased chronic neuroinflammation .

  • Less neuronal regeneration and decreased neurotrophic factors (BDNF).

  • Accumulation of toxic proteins that are not efficiently eliminated.

  • Decreased mental clarity, working memory, and motivation.

This inflammatory and degenerative state can begin decades before it is clinically detected, which is why prevention and early support are key .


Sevens products to protect the brain from cellular aging

Curcumin C3 Reduce Sevens

It crosses the blood-brain barrier. It modulates pathways such as NF-κB and reduces neuroinflammation. It stimulates autophagy and promotes the elimination of damaged proteins , such as beta-amyloid and tau.

Omega 3 Sevens (fish oil)

DHA is a key structural component of the brain. It enhances synapses, modulates the brain's immune response, and reduces cognitive decline associated with SASP.

Sevens Multivitamins

It provides B12, folic acid, B6, vitamin C, D and antioxidants that protect the nervous system and support methylation, essential for neuronal epigenetic balance.

Astaxanthin Sevens

It has a strong affinity for fatty tissues like the brain. It protects neuronal membranes from oxidative damage and improves mental acuity and memory.

Magnesium Sevens

It regulates synaptic transmission, neuronal plasticity, and circadian rhythm. It helps reduce brain overstimulation and improves functional connectivity.

Melatonin Sevens

Beyond regulating sleep, it acts as a neurocellular antioxidant and stimulates nocturnal autophagy in the brain , essential for the clearance of protein waste.

Creatine Sevens

Promotes rapid energy production in nerve cells. Improves mental clarity, motivation, and cognitive recovery. Very useful during periods of brain fatigue.


Conclusion

Brain senescence is one of the silent drivers of mental decline with age. Protecting the brain with ingredients capable of modulating inflammation, strengthening mitochondria, and restoring neuronal regeneration is a strategy for prevention and longevity. With Sevens, you can keep your mind clear, active, and resilient over time.