Cellular aging does not occur in isolation. Various interrelated processes reinforce each other, creating a vicious cycle that accelerates the body's functional decline. Among them, the interaction between oxidative stress and protein misfolding plays a central role.

Reactive oxygen species (ROS), commonly known as free radicals, are natural byproducts of cellular metabolism. In controlled amounts, they perform important signaling functions. However, when their production exceeds the body's antioxidant capacity—something that increasingly occurs with age— oxidative stress is generated, an imbalance that damages lipids, DNA, and, in particular, proteins.

What happens when proteins suffer oxidative damage?

Oxidative damage to proteins can lead to:

• Structural changes that alter its biological function.

• Exposure of hydrophobic regions that favor their aggregation.

• Loss of solubility, which prevents proper recycling.

These types of alterations interfere with the balance of proteostasis , leading to the progressive accumulation of damaged or misfolded proteins. These dysfunctional proteins are toxic to the cell, especially when they aggregate into structures resistant to degradation. This process has been shown to be involved in neurodegenerative diseases such as Alzheimer's, where beta-amyloid and tau deposits are paradigmatic examples of misfolded and oxidized proteins.

The accumulation of misfolded proteins is not just a byproduct of aging. It's a driving force. By disrupting intracellular communication, inducing inflammation, and blocking cellular recycling, these proteins accelerate tissue breakdown and contribute to the loss of organ function.

How to counteract this combination through nutrition and supplementation

The scientific literature has identified strategies to reduce the impact of oxidative stress on proteins and improve their functional stability:

• Increase endogenous antioxidant capacity , protecting proteins from oxidative damage.

• Promote the correct folding of proteins , reducing their vulnerability to stress.

• Stimulate the degradation of oxidized proteins , by activating autophagy or the proteasome.

Some nutrients and bioactive compounds that have proven useful in this context are:

• Selenium and zinc , both present in Sevens Multivitamins , participate in the synthesis of antioxidant enzymes such as glutathione peroxidase and superoxide dismutase, which are essential for neutralizing free radicals.

• Plant-based omega-3s , such as those found in Omega 3 Sevens , modulate inflammation and indirectly reduce ROS production in mitochondria.

• Magnesium , available in Magnesium Sevens , is a cofactor that improves metabolic efficiency, reducing the production of free radicals and promoting cell regeneration.

• Curcumin , the active ingredient in Curcumin Sevens , acts as a direct antioxidant and as a modulator of endogenous antioxidant pathways, such as the Nrf2 pathway.

Beyond supplements: lifestyle and diet as protective factors

• A diet rich in fruits, vegetables, nuts and seeds provides polyphenols, carotenoids and antioxidant vitamins (such as C and E) that reduce protein oxidation.

• Moderate physical activity stimulates the production of antioxidant enzymes and improves mitochondrial function, reducing the generation of ROS.

• Psychological stress management, restful sleep, and controlled exposure to environmental pollutants also contribute to reducing systemic oxidative burden.

Conclusion

The interaction between oxidative stress and misfolded proteins is not an inevitable consequence of aging, but rather a process that can be modulated with appropriate strategies. A diet rich in antioxidants, the use of strategic supplements, and habits that promote redox homeostasis can help maintain protein integrity and protect our cells from accelerated deterioration. Ultimately, this comprehensive approach represents an effective way to promote healthier, more functional aging, free from the consequences of cumulative damage.