Stem cells are the biological foundation of the human body. They are unspecialized cells capable of dividing indefinitely and differentiating into multiple cell types. Thanks to them, we can regenerate tissues, repair injuries, maintain functional organs, and adapt to physiological stress . They are key to the renewal of muscles, skin, the intestines, the nervous system, and the immune system.
But with age, the quantity and quality of our stem cells decline . This progressive depletion limits the body's ability to regenerate, facilitating the onset of degenerative diseases, loss of muscle mass, frailty, cognitive decline, and visible aging.
Block 8 – Stem Cell Depletion
This section explores why stem cells deplete, how this affects different tissues, what factors accelerate their decline, and what natural strategies can protect or reactivate them. Over 10 articles, we'll develop a comprehensive, science-based approach to maintaining the body's regenerative capacity over time .
Index of articles in block 8:
8.1. What are stem cells and why do they deplete with age?
8.2. The role of muscle stem cells in loss of mass and strength
8.3. Stem cells and brain aging: plasticity, memory, and neurogenesis
8.4. The intestinal stem cell niche: key to regeneration and immunity
8.5. Factors that damage stem cells: inflammation, toxins, and oxidative stress
8.6. How sleep and circadian rhythms affect stem cell renewal
8.7. Stem cells in the skin: visible aging and regenerative capacity
8.8. Physical exercise and stimulation of endogenous stem cells
8.9. Nutrients that support longevity and stem cell function
8.10. Comprehensive Sevens Strategy to Protect and Revitalize Stem Cells
Why stem cells become depleted over time
Stem cell depletion is due to a combination of factors:
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Accumulation of DNA damage and telomere shortening.
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Decrease in local regenerative signals.
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Increased inflammation and oxidative stress in the niches where they reside.
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Reduced ability of stem cells to divide or differentiate.
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Mitochondrial dysfunction, epigenetic alterations and systemic aging.
This not only reduces their number, but also their functional quality: they lose the ability to respond to injury, repair tissues, or maintain the balance of key organs such as the skin, intestines, or brain.
How Sevens supports stem cell protection
An adequate strategy should:
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Protect the cellular environment (niche).
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Support mitochondrial function.
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Modulate inflammation and oxidative stress.
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Promote proper circadian rhythms and regenerative signals.
Sevens Multivitamins
It provides essential nutrients (vitamins B, C, D, A, zinc, selenium) to maintain the enzymatic and epigenetic activity of stem cells.
Curcumin C3 Reduce Sevens
It modulates regeneration pathways such as AMPK and NRF2. It helps maintain cellular plasticity and protects against inflammatory signals that deplete stem cell niches.
Melatonin Sevens
It promotes nighttime renewal, improves mitophagy, and stimulates endogenous regeneration. It helps preserve the number and vitality of stem cells in the nervous system and other tissues.
Omega 3 Sevens (fish oil)
It reduces inflammation in stem cell niches, preserves the integrity of cell membranes, and improves the adaptive response to damage.
Astaxanthin Sevens
Powerful antioxidant that protects stem cell DNA from mitochondrial oxidative stress, promoting their longevity and function.
D3 + K2 Sevens
It stimulates immunomodulation, protects the bone and vascular environment, and supports the health of the regenerative microenvironment .
Conclusion
Aging is not just a matter of wear and tear, but of a decline in our ability to repair ourselves . Stem cells are that vital reservoir of renewal. Preserving them means preserving the body's functional youthfulness. With a combined strategy of cellular nutrition, rest, inflammation reduction, and adequate supplementation, like the one Sevens proposes, we can protect the body's regenerative capacity and slow aging at its root.