When we talk about cellular longevity, few things are as relevant as the quality of the proteins we consume and the way our bodies utilize them. Dietary proteins are composed of amino acids, the essential building blocks for tissue repair, enzyme synthesis, maintaining the immune system, and preserving cellular function. Without an adequate supply of these components, the cellular machinery that regulates proteostasis —the balance of protein production, folding, and degradation—loses efficiency.

The deterioration of this balance is a central feature of aging, but it is also a pathway that can be modulated through nutrition, especially by optimizing the type, quantity, and timing of amino acid intake.

The importance of the amino acid profile

Not all proteins are created equal. Those with high biological value—such as those from eggs, fish, or certain combined plant sources—contain all the essential amino acids , those the body cannot synthesize on its own. Among these, leucine and methionine have received special attention in aging research:

• Leucine activates the mTOR pathway, a key regulator of protein synthesis, muscle mass, and cell regeneration.

• Methionine , although essential, has been shown to be restricted (without causing deficiency) and can extend lifespan in animal models, probably by activating autophagy mechanisms and reducing oxidative stress.

A balanced, moderate intake tailored to individual needs appears to be the key to maintaining protein health without overstimulating anabolic pathways that could accelerate aging.

Proteostasis and protein requirements in adulthood and old age

As we age, the efficiency with which we metabolize protein decreases. This means that older adults may require slightly higher protein intake to maintain muscle mass and cell function. However, the source and digestibility become even more important.

Recent studies have shown that evenly distributing protein throughout the day, with a minimum of 25-30 g per meal, helps maintain muscle protein synthesis and can reduce the accumulation of misfolded proteins by improving overall protein turnover.

Strategies to improve amino acid utilization and support proteostasis

• Maintain an adequate intake of complete proteins , combining plant sources such as legumes and grains with high-quality animal or plant sources.

• Incorporate foods rich in tryptophan , glutamine and taurine , amino acids involved in neurometabolic balance, immune response and cellular protection.

• Stimulate regulatory pathways such as AMPK and mTOR in a cyclical manner, alternating periods of high-protein eating with lighter ones, or even strategies such as intermittent fasting, under professional supervision.

Complementary supplementation to preserve cellular protein quality

Although Sevens doesn't offer complete protein supplements or specific amino acids (yet...), its line contributes to protein metabolism from several angles:

• Sevens Multivitamins : Includes B6, B12 and folic acid, all involved in amino acid metabolism and epigenetic regulation associated with longevity.

• Magnesium Sevens : participates in protein synthesis and the efficient use of amino acids at the cellular level.

• Omega 3 Sevens : improves insulin signaling and mitochondrial function, necessary conditions for optimal nutrient utilization.

Furthermore, controlling the inflammatory and oxidative environment—through supplements like Curcumin Sevens —promotes a cellular environment that reduces stress on newly synthesized proteins, preventing misfolding.

Conclusion

The quality of the proteins we consume and how we process them has a direct impact on our ability to maintain healthy proteostasis throughout life. Understanding the role of amino acids in regulating aging allows us to design smarter, more sustainable nutritional strategies aimed at preserving cellular function. With conscious eating and the support of strategic supplements, it is possible to strengthen the foundations of longevity from the very foundation of our cells.